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Research shows NNMT overexpression is associated with various metabolic dysfunction states, so its inhibition is useful for understanding these processes

Psychiatry 28 , 19021918 (2023)

It is still not clear whether erythrocytes can undergo a distinct iron-driven cell death or whether iron-mediated mechanisms contribute to execution of eryptosis

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Because the pituitary remains largely unaffected and is able to maintain intracellular T3 levels while the rest of the body suffers from significantly reduced intracellular T3 levels, there is no elevation in thyroid-stimulating hormone (TSH) despite the presence of wide-spread tissue hypothyroidism, making the TSH and other standard blood tests a poor marker to determine the presence or absence of hypothyroidism